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CIK - Cytokine-induced killer
Universität Bonn
Universitätsklinikum Bonn

References

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Chen, J., Huang, X., Huang, G. C., Chen, Y. T., Chen, L. B., & Song, H. Z. (2012). Preconditioning Chemotherapy with Cisplatin Enhances the Antitumor Activity of Cytokine-Induced Killer Cells in a Murine Melanoma Model. Cancer Biotherapy and Radiopharmaceuticals, 27(3), 210-220. doi:10.1089/cbr.2011.1116


Chen, Q., Cui, X. X., Liang, P. F., Dou, J. X., Liu, Z. Y., & Sun, W. W. (2016). Immunotherapy with dendritic cells and cytokine-induced killer cells for MDA-MB-231 breast cancer stem cells in nude mice. American Journal of Translational Research, 8(7), 2947-2955. Retrieved from <Go to ISI>://WOS:000381647300008


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Gammaitoni, L., Giraudo, L., Macagno, M., Leuci, V., Mesiano, G., Rotolo, R., . . . Sangiolo, D. (2017). Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells. Clinical Cancer Research, 23(9), 2277-2288. doi:10.1158/1078-0432.Ccr-16-1524


Golay, J., Martinelli, S., Alzani, R., Cribioli, S., Albanese, C., Gotti, E., . . . Introna, M. (2018). Cord blood-derived cytokine-induced killer cells combined with blinatumomab as a therapeutic strategy for CD19(+) tumors. Cytotherapy, 20(8), 1077-1088. doi:10.1016/j.jcyt.2018.06.003


He, M., Wang, Y., Shi, W. J., Wang, S. J., Sha, H. F., Feng, J. X., & Wang, J. (2011). Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction. Journal of Digestive Diseases, 12(5), 393-400. doi:10.1111/j.1751-2980.2011.00527.x


He, Q. S., Yi, T. N., Zhang, J., & Zhao, J. (2016). Anti-tumor effects of DC-CIK cell in combination with PXT/DDP against ovarian cancer in mice. International Journal of Clinical and Experimental Pathology, 9(9), 8824-8835. Retrieved from <Go to ISI>://WOS:000386654900007


Helms, M. W., Prescher, J. A., Cao, Y. A., Schaffert, S., & Contag, C. H. (2010). IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy. Cancer Immunology Immunotherapy, 59(9), 1325-1334. doi:10.1007/s00262-010-0860-y


Hoyle, C., Bangs, C. D., Chang, P., Kamel, O., Mehta, B., & Negrin, R. S. (1998). Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: In vitro and in vivo efficacy in severe combined immunodeficiency disease mice. Blood, 92(9), 3318-3327. doi:10.1182/blood.V92.9.3318.421k39_3318_3327


Hu, H. Z., Qiu, Y. H., Guo, M. G., Huang, Y., Fang, L., Peng, Z. X., . . . Su, C. Q. (2015). Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models. Oncotarget, 6(2), 1079-1089. doi:10.18632/oncotarget.2835


Huang, F., Wang, B., Zeng, J. Z., Sang, S. G., Lei, J. H., & Lu, Y. D. (2018). MicroRNA-374b inhibits liver cancer progression via down regulating programmed cell death-1 expression on cytokine-induced killer cells. Oncology Letters, 15(4), 4797-4804. doi:10.3892/ol.2018.7951


Huang, X., Chen, Y. T., Song, H. Z., Huang, G. C., & Chen, L. B. (2011). Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells. World Journal of Gastroenterology, 17(25), 3002-3011. doi:10.3748/wjg.v17.i25.3002


Huang, X., Cui, S. Y., & Shu, Y. Q. (2016). Cisplatin selectively downregulated the frequency and immunoinhibitory function of myeloid-derived suppressor cells in a murine B16 melanoma model. Immunologic Research, 64(1), 160-170. doi:10.1007/s12026-015-8734-1


Jin, J., Joo, K. M., Lee, S. J., Jo, M. Y., Kim, Y., Jin, Y., . . . Nam, D. H. (2011). Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma. Oncology Reports, 25(1), 33-39. doi:10.3892/or_00001038


Jung, N. C., Lee, J. H., Choi, H. J., Hwang, S. U., Song, J. Y., Seo, H. G., . . . Lim, D. S. (2016). Dendritic Cell Immunotherapy Combined with Cytokine-Induced Killer Cells Effectively Suppresses Established Hepatocellular Carcinomas in Mice. Immunological Investigations, 45(6), 553-565. doi:10.1080/08820139.2016.1183025


Kim, H. M., Kang, J. S., Lim, J., Kim, J. Y., Kim, Y. J., Lee, S. J., . . . Han, S. B. (2009). Antitumor activity of cytokine-induced killer cells in nude mouse xenograft model. Archives of Pharmacal Research, 32(5), 781-787. doi:10.1007/s12272-009-1518-1


Kim, H. M., Kang, J. S., Lim, J., Park, S. K., Lee, K., Yoon, Y. D., . . . Han, S. B. (2007). Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Archives of Pharmacal Research, 30(11), 1464-1470. doi:10.1007/bf02977372


Kim, H. M., Lim, J., Kang, J. S., Park, S. K., Lee, K., Kim, J. Y., . . . Han, S. B. (2009). Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model. International Immunopharmacology, 9(3), 375-380. doi:10.1016/j.intimp.2008.12.001


Kim, H. M., Lim, J., Park, S. K., Kang, J. S., Lee, K., Lee, C. W., . . . Han, S. B. (2007). Antitumor activity of cytokine-induced killer cells against human lung cancer. International Immunopharmacology, 7(13), 1802-1807. doi:10.1016/j.intimp.2007.08.016


Kim, H. M., Lim, J., Yoon, Y. D., Ahn, J. M., Kang, J. S., Lee, K., . . . Han, S. B. (2007). Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma. International Immunopharmacology, 7(13), 1793-1801. doi:10.1016/j.intimp.2007.08.007


Kim, J. S., Chung, I. S., Lim, S. H., Park, Y., Park, M. J., Kim, J. Y., . . . Han, S. B. (2014). Preclinical and clinical studies on cytokine-induced killer cells for the treatment of renal cell carcinoma. Archives of Pharmacal Research, 37(5), 559-566. doi:10.1007/s12272-014-0381-x


Kim, J. S., Kim, Y. G., Lee, H. K., Park, E. J., Kim, B., Kang, J. S., . . . Han, S. B. (2017). Cytokine-induced killer cells hunt individual cancer cells in droves in a mouse model. Cancer Immunology Immunotherapy, 66(2), 193-202. doi:10.1007/s00262-016-1934-2


Kim, Y. J., Lim, J., Kang, J. S., Kim, H. M., Lee, H. K., Ryu, H. S., . . . Han, S. B. (2010). Adoptive Immunotherapy of Human Gastric Cancer with Ex Vivo Expanded T Cells. Archives of Pharmacal Research, 33(11), 1789-1795. doi:10.1007/s12272-010-1111-7


Lee, D. H., Nam, J. Y., Chang, Y., Cho, H., Kang, S. H., Cho, Y. Y., . . . Yoon, J. H. (2017). Synergistic effect of cytokine-induced killer cell with valproate inhibits growth of hepatocellular carcinoma cell in a mouse model. Cancer Biology & Therapy, 18(1), 67-75. doi:10.1080/15384047.2016.1276132


Lee, H. K., Kim, Y. G., Kim, J. S., Park, E. J., Kim, B., Park, K. H., . . . Han, S. B. (2016). Cytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling. Cancer Letters, 378(2), 142-149. doi:10.1016/j.canlet.2016.05.020


Leuci, V., Casucci, G. M., Grignani, G., Rotolo, R., Rossotti, U., Vigna, E., . . . Sangiolo, D. (2018). CD44v6 as innovative sarcoma target for CAR-redirected CIK cells. Oncoimmunology, 7(5). doi:10.1080/2162402x.2017.1423167


Li, Y., Huang, S. L., Fang, J. P., Zhang, X. C., Wei, J., Huang, W. G., . . . Yin, S. M. (2005). Using the NOD/SCID mice model of human erythroleukemia for evaluating the cytotoxicity activity of CB-CIK/NK cells stimulated by K562-DCs fusion vaccines. Blood, 106(11), 394B-394B. doi:10.1182/blood.V106.11.5240.5240


Li, Y., Qu, Y. H., Wu, Y. F., Wang, X. P., Wei, J., Huang, W. G., . . . Huang, S. L. (2011). Bone marrow mesenchymal stem cells reduce the antitumor activity of cytokine-induced killer/natural killer cells in K562 NOD/SCID mice. Annals of Hematology, 90(8), 873-885. doi:10.1007/s00277-011-1156-9


Lin, X. R., Zhou, X. L., Feng, Q., Pan, X. Y., Song, S. L., Fang, H., . . . Yang, J. L. (2019). CIK cell-based delivery of recombinant adenovirus KGHV500 carrying the anti-p21Ras scFv gene enhances the anti-tumor effect and safety in lung cancer. Journal of Cancer Research and Clinical Oncology, 145(5), 1123-1132. doi:10.1007/s00432-019-02857-8


Liu, C. S., Suksanpaisan, L., Chen, Y. W., Russell, S. J., & Peng, K. W. (2013). Enhancing cytokine-induced killer cell therapy of multiple myeloma. Experimental Hematology, 41(6), 508-517. doi:10.1016/j.exphem.2013.01.010


Liu, C. Y., Zheng, Y. Y., Tang, J. Y., Wang, D. W., Ma, Z. S., Li, S. T., & Chang, X. T. (2019). Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer. Journal of Immunology Research. doi:10.1155/2019/6587570


Liu, F. R., Bai, S., Feng, Q., Pan, X. Y., Song, S. L., Fang, H., . . . Yang, J. L. (2018). Anti-colorectal cancer effects of anti-p21Ras scFv delivered by the recombinant adenovirus KGHV500 and cytokine-induced killer cells. Bmc Cancer, 18. doi:10.1186/s12885-018-4989-y


Liu, P. Y., Chen, L. B., & Huang, X. (2009). The Antitumor Effects of CIK Cells Combined with Docetaxel Against Drug-Resistant Lung Adenocarcinoma Cell Line SPC-A1/DTX in Vitro and in Vivo. Cancer Biotherapy and Radiopharmaceuticals, 24(1), 91-97. doi:10.1089/cbr.2008.0533


Liu, X. Y., Hu, J. X., Cao, W. H., Qu, H. L., Wang, Y., Ma, Z. L., & Li, F. N. (2013). Effects of two different immunotherapies on triple negative breast cancer in animal model. Cellular Immunology, 284(1-2), 111-118. doi:10.1016/j.cellimm.2013.07.018


Ma, C. J., Wei, Y. L., Lui, Q., Xin, Y. Z., Gao, G. S., Wang, X., & Yang, P. M. (2019). Polysaccharides from Hedyotis diffusa enhance the antitumor activities of cytokine-induced killer cells. Biomedicine & Pharmacotherapy, 117. doi:10.1016/j.biopha.2019.109167


Ma, P., He, Q., Li, W., Li, X. L., Han, H. M., Jin, M. M., . . . Gao, B. (2015). Anti-CD3 x EGFR bispecific antibody redirects cytokine-induced killer cells to glioblastoma in vitro and in vivo. Oncology Reports, 34(5), 2567-2575. doi:10.3892/or.2015.4233


Oelsner, S., Wagner, J., Friede, M. E., Pfirrmann, V., Genssler, S., Rettinger, E., . . . Wels, W. S. (2016). Chimeric antigen receptor-engineered cytokine-induced killer cells overcome treatment resistance of pre-B-cell acute lymphoblastic leukemia and enhance survival. International Journal of Cancer, 139(8), 1799-1809. doi:10.1002/ijc.30217


Peng, Z., Liang, W. T., Li, Z. X., Xu, Y. X., & Chen, L. (2016). Interleukin-15-transferred cytokine-induced killer cells elevated anti-tumor activity in a gastric tumor-bearing nude mice model. Cell Biology International, 40(2), 204-213. doi:10.1002/cbin.10553


Ren, X. Q., Ma, W. L., Lu, H., Yuan, L., An, L., Wang, X. C., . . . Zuo, S. G. (2015). Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies. Cancer Immunology Immunotherapy, 64(12), 1517-1529. doi:10.1007/s00262-015-1757-6


Rettinger, E., Kreyenberg, H., Merker, M., Kuci, S., Willasch, A., Bug, G., . . . Bader, P. (2014). Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion. Cytotherapy, 16(6), 835-844. doi:10.1016/j.jcyt.2014.01.003


Rettinger, E., Kuci, S., Kreyenberg, H., Anzaghe, M., Willasch, A., Klingebiel, T., & Bader, P. (2011). Cytotoxic capability of IL15 stimulated CIK cells in humanized NOD/SCID/IL2R gamma(null) mice transplanted with rhabdomyosarcoma and acute myeloid leukaemia cells. Bone Marrow Transplantation, 46, S322-S323. Retrieved from <Go to ISI>://WOS:000289195402210


Rong, X. X., Wei, F., Lin, X. L., Qin, Y. J., Chen, L., Wang, H. Y., . . . Xiao, D. (2016). Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition. Oncoimmunology, 5(3). doi:10.1080/2162402x.2015.1086060


Sangiolo, D., Mesiano, G., Gammaitoni, L., Leuci, V., Todorovic, M., Giraudo, L., . . . Grignani, G. (2014). Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas. Cancer Research, 74(1), 119-129. doi:10.1158/0008-5472.Can-13-1559


Shan, C. C., Shi, L. R., Ding, M. Q., Zhu, Y. B., Li, X. D., Xu, B., . . . Wu, C. P. (2015). Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response. Oncology Letters, 9(4), 1549-1556. doi:10.3892/ol.2015.2977


Shi, S. J., Tao, L. L., Song, H. Z., Chen, L. B., & Huang, G. C. (2014). Synergistic antitumor effect of combining metronomic chemotherapy with adoptive cell immunotherapy in nude mice. Apmis, 122(5), 380-391. doi:10.1111/apm.12235


Sun, W. W., Dou, J. X., Zhang, L., Qiao, L. K., Shen, N., Zhao, Q., & Gao, W. Y. (2017). Killing effects of Huaier Granule combined with DC-CIK on nude mice transplanted with colon carcinoma cell line. Oncotarget, 8(28), 46081-46089. doi:10.18632/oncotarget.17687


Wang, F. S., Liu, M. X., Zhang, B., Shi, M., Lei, Z. Y., Sun, W. B., . . . Chen, J. M. (2002). Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo. World Journal of Gastroenterology, 8(3), 464-468. doi:10.3748/wjg.v8.i3.464


Wang, J., He, M., Shi, W. J., Sha, H. F., Feng, J. X., Wang, S. J., & Wang, Y. (2009). Inducible Costimulator (ICOS) Enhances the Cytolytic Activity of Cytokine-Induced Killer Cells Against Gallbladder Cancer In Vitro and In Vivo. Cancer Investigation, 27(3), 244-250. doi:10.1080/07357900802239124


Wang, P., Yu, J. P., Gao, S. Y., An, X. M., Ren, X. B., Wang, X. G., & Li, W. L. (2008). Experimental study on the treatment of intracerebral glioma xenograft with human cytokine-induced killer cells. Cellular Immunology, 253(1-2), 59-65. doi:10.1016/j.cellimm.2008.04.014


Wang, Y., Dai, H. R., Li, H., Lv, H. Y., Wang, T., Fu, X. B., & Han, W. D. (2011). Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells. Clinical & Developmental Immunology. doi:10.1155/2011/621414


Wei, C. Y., Wang, W. J., Pang, W., Meng, M. Y., Jiang, L. H., Xue, S., . . . Hou, Z. L. (2014). The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma. Tumor Biology, 35(3), 1997-2007. doi:10.1007/s13277-013-1265-2


Wei, F., Rong, X. X., Xie, R. Y., Jia, L. T., Wang, H. Y., Qin, Y. J., . . . Xiao, D. (2015). Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition. Oncotarget, 6(33), 35023-35039. doi:10.18632/oncotarget.5280


Wongkajornsilp, A., Somchitprasert, T., Butraporn, R., Wamanuttajinda, V., Kasetsinsombat, K., Huabprasert, S., . . . Hongeng, S. (2009). Human Cytokine-Induced Killer Cells Specifically Infiltrated and Retarded the Growth of the Inoculated Human Cholangiocarcinoma Cells in SCID Mice. Cancer Investigation, 27(2), 140-148. doi:10.1080/07357900802189832


Xia, F. F., Hou, W. X., Liu, Y. L., Wang, W. T., Han, Y., Yang, M., . . . Cui, D. X. (2018). Cytokine induced killer cells-assisted delivery of chlorin e6 mediated self-assembled gold nanoclusters to tumors for imaging and immuno-photodynamic therapy. Biomaterials, 170, 1-11. doi:10.1016/j.biomaterials.2018.03.048


Yang, T., Zhang, W. J., Wang, L., Xiao, C. Y., Wang, L., Gong, Y., . . . Nan, Y. Y. (2018). Co-culture of dendritic cells and cytokine-induced killer cells effectively suppresses liver cancer stem cell growth by inhibiting pathways in the immune system. Bmc Cancer, 18. doi:10.1186/s12885-018-4871-y


Yoon, S. H., Lee, J. M., Woo, S. J., Park, M. J., Park, J. S., Kim, H. S., . . . Kim, T. G. (2009). Transfer of Her-2/neu Specificity into Cytokine-Induced Killer (CIK) Cells with RNA Encoding Chimeric Immune Receptor (CIR). Journal of Clinical Immunology, 29(6), 806-814. doi:10.1007/s10875-009-9308-6


Yu, S. J., Ma, C., Heinrich, B., Brown, Z. J., Sandhu, M., Zhang, Q. F., . . . Greten, T. F. (2019). Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma. Journal of Hepatology, 70(3), 449-457. doi:10.1016/j.jhep.2018.10.040


Yuan, Y. H., Zhou, C. F., Yuan, J., Liu, L., Guo, X. R., Wang, X. L., . . . Tu, H. J. (2016). NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells. Oncology Letters, 12(5), 3167-3174. doi:10.3892/ol.2016.5112


Zhang, H. Z., Guo, M. L., Chen, H. Y., Zhang, Y., & He, L. Y. (2016). Effects of CIK on hypoxia inducible factor-1 alpha and T-cell subsets on colon 26 cancer xenograft mice. Oncology Letters, 11(2), 1371-1374. doi:10.3892/ol.2016.4081


Zhang, W., Song, Z. H., Xiao, J. P., Liu, X. H., Luo, Y., Yang, Z. K., . . . Li, A. M. (2019). Blocking the PD-1/PD-L1 axis in dendritic cell-stimulated Cytokine-Induced Killer Cells with pembrolizumab enhances their therapeutic effects against hepatocellular carcinoma. Journal of Cancer, 10(11), 2578-2587. doi:10.7150/jca.26961


Zhang, X. L., Du, M. H., Zhang, Q., Chen, H. Y., Zhao, L., Li, H. J., & Guo, W. S. (2017). In vivo anti-tumor effect of DC-CIK cells on human lymphoma cell line Raji. Pakistan Journal of Pharmaceutical Sciences, 30(3), 1075-1079. Retrieved from <Go to ISI>://WOS:000407186800007


Zhang, X. M., Yang, Y. S., Yang, C., & Sun, G. (2013). Inhibition of human esophageal cancer growth by cytokine-induced killer cells in xenograft nude mice. Journal of Gastroenterology and Hepatology, 28, 864-865. Retrieved from <Go to ISI>://WOS:000325017805148


Zhang, Z., Zhao, X. L., Zhang, T. F., Wang, L. P., Yang, L. Z., Huang, L., . . . Zhang, Y. (2015). Phenotypic characterization and anti-tumor effects of cytokine-induced killer cells derived from cord blood. Cytotherapy, 17(1), 86-97. doi:10.1016/j.jcyt.2014.09.006


Zhao, J. J., Pan, K., Wang, Q. J., Xu, Z. D., Weng, D. S., Li, J. J., . . . Xia, J. C. (2013). Effect of anti-asthma Chinese medicine Chuankezhi on the anti-tumor activity of cytokine-induced killer cells. Chinese Journal of Cancer, 32(10), 553-560. doi:10.5732/cjc.012.10249


Zhao, P., Zhu, D. N., Zhang, Z., Han, B., Gao, D. Q., Wei, X. F., . . . Guo, Q. M. (2017). Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4(+)CD25(bri) regulatory T cells. Immunology Letters, 181, 36-44. doi:10.1016/j.imlet.2016.11.009


Zhen, Z. J., Yang, K. B., Ye, L. T., You, Z. Y., Chen, R. R., Liu, Y., & He, Y. J. (2017). HLA-E inhibitor enhances the killing of neuroblastoma stem cells by co-cultured dendritic cells and cytokine-induced killer cells loaded with membrane-based microparticles. American Journal of Cancer Research, 7(2), 334-345. Retrieved from <Go to ISI>://WOS:000396834200013


Zheng, Y., Hu, B. C., Xie, S. G., Chen, X. F., Hu, Y. Q., Chen, W. P., . . . Hu, B. (2017). Dendritic cells infected by Ad-sh-SOCS1 enhance cytokine-induced killer (CIK) cell immunotherapeutic efficacy in cervical cancer models. Cytotherapy, 19(5), 617-628. doi:10.1016/j.jcyt.2017.01.008


Zhu, B. Q., Ju, S. W., & Shu, Y. Q. (2009). CD137 enhances cytotoxicity of CD3(+)CD56(+) cells and their capacities to induce CD4(+) Th1 responses. Biomedicine & Pharmacotherapy, 63(7), 509-516. doi:10.1016/j.biopha.2008.10.003


Zou, Y., Li, F., Hou, W., Sampath, P., Zhang, Y., & Thorne, S. H. (2014). Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells. British Journal of Cancer, 110(8), 1992-1999. doi:10.1038/bjc.2014.140


Zuo, S. G., Wen, Y. Q., Panha, H., Dai, G. P., Wang, L. P., Ren, X. Q., & Fu, K. D. (2017). Modification of cytokine-induced killer cells with folate receptor alpha (FR alpha)-specific chimeric antigen receptors enhances their antitumor immunity toward FR alpha-positive ovarian cancers. Molecular Immunology, 85, 293-304. doi:10.1016/j.molimm.2017.03.017