Clinical trials using CIK cells with tumor entity and number of patients
Tumor entity |
Reference |
Phase |
Total number of patients treated with CIK cells |
|---|---|---|---|
| Hepatocellular carcinoma | M. Shi et al., 2004 | na | 13 |
| Olioso et al., 2009 | pilot | 1 | |
| Hui, Qiang, Jian, Ti, & Da-Lu, 2009 | na | 84 | |
| C. Pan et al., 2010 | na | 42 | |
| Hao et al., 2010 | na | 72 | |
| J. Yu et al., 2011 | na | 2 | |
| Niu et al., 2011 | na | 1 | |
| P. Zhou et al., 2011 | I | 10 | |
| Qiu et al., 2011 | na | 9 | |
| Jinying Zhang et al., 2012 | retrospective | 2 | |
| K. Pan et al., 2013 | retrospective | 204 | |
| X. Yu et al., 2014 | II | 66 | |
| Z. Zhang et al., 2015 | retrospective | 2 | |
| Lee et al., 2015 | III | 114 | |
| Y. Liu et al., 2016 | retrospective | 3 | |
| Jian Zhang et al., 2018 | retrospective | 20 | |
| C.-L. Chen et al., 2018 | I | 9 | |
| Z. Zhou, Qin, Weng, & Ni, 2019 | retrospective | 35 | |
| Yoon et al., 2019 | IV | 59 | |
| C. Li et al., 2019 | na | 11 | |
|
Renal cell carcinoma |
Schmidt-Wolf et al., 1999 | I | 1 |
| Olioso et al., 2009 | pilot | 5 | |
| Su et al., 2010 | na | 16 | |
| Jinying Zhang et al., 2012 | na | 10 | |
| Zhan et al., 2012 | na | 46 | |
| L. Liu et al., 2012 | na | 74 | |
| Y. Zhang et al., 2013 | na | 10 | |
| Z. Wang et al., 2014 | na | 29 | |
| D. Wang et al., 2014 | na | 28 | |
| X. Zhao et al., 2015 | na | 61 | |
| Zheng et al., 2015 | na | 154 | |
| Hong, Na-na, & Xin-hua, 2016 | na | 20 | |
| C.-L. Chen et al., 2018 | I | 8 | |
| Mai et al., 2018 | retrospective | 19 | |
| Z. Wang et al., 2018 | na | 1 | |
| C. Li et al., 2019 | na | 6 | |
| Acute lymphoblastic leukemia | Introna et al., 2007 | I | 1 |
| Laport et al., 2011 | na | 2 | |
| Y. Linn et al., 2012 | I / II | 3 | |
| Y. Luo et al., 2016 | I | 2 | |
| Introna et al., 2017 | II a | na | |
| Acute myelogenous leukemia | Introna et al., 2007 | I | 4 |
| Introna et al., 2010 | na | 4 | |
| Laport et al., 2011 | na | 3 | |
| B. Yang et al., 2012 | pilot | 1 | |
| Y. Linn et al., 2012 | I / II | 8 | |
| Dong et al., 2012 | na | 21 | |
| Y.-C. Linn et al., 2012 | I / II | 13 | |
| Y. Wang et al., 2013 | na | 2 | |
| Y. Luo et al., 2016 | I | 4 | |
| Introna et al., 2017 | II a | na | |
| Narayan et al., 2019 | II | 12 | |
| Chronic lymphoblastic leukemia | Laport et al., 2011 | na | 2 |
| Chronic myelogenous leukemia | Introna et al., 2007 | I | 1 |
| B. Yang et al., 2012 | pilot | 3 | |
| Y. Linn et al., 2012 | I / II | 1 | |
| Y.-C. Linn et al., 2012 | I / II | 11 | |
| Y. Luo et al., 2016 | I | 3 | |
| Lymphoma | Schmidt-Wolf et al., 1999 | I | 2 |
| Leemhuis, Wells, Scheffold, Edinger, & Negrin, 2005 | I | 9 | |
| Introna et al., 2007 | I | 3 | |
| Olioso et al., 2009 | pilot | 6 | |
| Guo et al., 2011 | na | 8 | |
| J. Yu et al., 2011 | na | 1 | |
| Laport et al., 2011 | na | 6 | |
| Y. Linn et al., 2012 | I / II | 4 | |
| Jinying Zhang et al., 2012 | na | 1 | |
| B. Yang et al., 2012 | pilot | 9 | |
| Lu et al., 2012 | na | 9 | |
| Qiu et al., 2016 | na | 14 | |
| Y. Luo et al., 2016 | I | 4 | |
| F. Chen et al., 2017 | na | 3 | |
| Introna et al., 2017 | II a | na | |
| Pfeffermann et al., 2018 | na | 1 | |
| Bladder cancer | Jinying Zhang et al., 2012 | na | 1 |
| C.-L. Chen et al., 2018 | I | 2 | |
| Breast cancer | Niu et al., 2011 | na | 1 |
| Jinying Zhang et al., 2012 | na | 1 | |
| K. Pan et al., 2014 | retrospective | 45 | |
| Ren et al., 2013 | na | 87 | |
| Hong et al., 2016 | na | 9 | |
| F. Chen et al., 2017 | na | 8 | |
| C.-L. Chen et al., 2018 | na | 1 | |
| C.-L. Chen et al., 2018 | na | 4 | |
| Cervival cancer | Niu et al., 2011 | na | 1 |
| N. Li et al., 2019 | na | 44 | |
| Colorectal cancer | Niu et al., 2011 | na | 2 |
| Jinying Zhang et al., 2012 | na | 4 | |
| Y. Zhu et al., 2013 | retrospective | 21 | |
| H. Zhu et al., 2014 | na | 100 | |
| Gao et al., 2014 | na | na | |
| Jinying Zhang et al., 2014 | na | 30 | |
| Z. Zhang et al., 2015 | retrospective | 5 | |
| Lin, Song, Chuo, Zhang, & Zhao, 2016 | prospective | 134 | |
| H. Zhao et al., 2016 | II | 61 | |
| Y. Liu et al., 2016 | retrospective | 18 | |
| C. Zhang et al., 2017 | na | 3 | |
| Xie et al., 2017 | retrospective | 71 | |
| C.-L. Chen et al., 2018 | I | 6 | |
| C. Li et al., 2019 | na | 12 | |
| C.-L. Chen et al., 2018 | I | 6 | |
| Esophagus cancer | Z. Zhang et al., 2015 | retrospective | 1 |
| Y. Liu et al., 2016 | retrospective | 7 | |
| C. Zhang et al., 2017 | na | 1 | |
| Gallbladder cancer | Niu et al., 2011 | na | 1 |
| Y. Liu et al., 2016 | retrospective | 4 | |
| Gastric cancer | J. Jiang et al., 2006 | na | 32 |
| J.-T. Jiang et al., 2010 | na | 75 | |
| J. Yu et al., 2011 | na | 2 | |
| Jinying Zhang et al., 2012 | na | 6 | |
| L. Shi et al., 2012 | na | 74 | |
| H. Liu, Song, Yang, & Zhang, 2013 | na | 51 | |
| H. Zhao et al., 2013 | retrospective | 53 | |
| Gao et al., 2014 | na | na | |
| Z. Zhang et al., 2015 | retrospective | 1 | |
| Cui et al., 2015 | pilot | 30 | |
| Y. Liu et al., 2016 | retrospective | 14 | |
| Xu et al., 2016 | II | 16 | |
| Mu et al., 2016 | na | 13 | |
| Hong et al., 2016 | na | 6 | |
| Y. Chen et al., 2016 | retrospective | 95 | |
| C. Li et al., 2019 | na | 19 | |
| Qiao et al., 2019 | prospective | 30 | |
| Glioblastoma | Kong et al., 2017 | III | 91 |
| F. Chen et al., 2017 | na | 1 | |
| Lung cancer | Wu, Jiang, Shi, & Xu, 2008 | prospective | 29 |
| Hui Li et al., 2009 | na | 42 | |
| J. Yu et al., 2011 | na | 9 | |
| Zhong, Teng, Han, & Zhong, 2011 | na | 14 | |
| Niu et al., 2011 | na | 8 | |
| S. B. Shi, Ma, Li, & Tang, 2012 | na | 30 | |
| Jinying Zhang et al., 2012 | na | 3 | |
| R. Li et al., 2012 | II | 87 | |
| L. Yang et al., 2013 | na | 61 | |
| Jin et al., 2014 | na | 411 | |
| Zhong, Han, & Zhong, 2014 | prospective | 60 | |
| J. Zhang et al., 2015 | retrospective | 60 | |
| Z. Zhang et al., 2015 | retrospective | 1 | |
| P. Zhao et al., 2015 | na | 25 | |
| H. Luo et al., 2016 | retrospective | 70 | |
| Hong et al., 2016 | na | 10 | |
| Y. Liu et al., 2016 | retrospective | 6 | |
| L. Zhang et al., 2016 | na | 21 | |
| Gu et al., 2017 | na | 32 | |
| C. Zhang et al., 2017 | na | 4 | |
| F. Chen et al., 2017 | na | 12 | |
| C. Zhang et al., 2017 | na | 4 | |
| Huang et al., 2017 | retrospective | 22 | |
| D. Chen et al., 2018 | na | 68 | |
| C.-L. Chen et al., 2018 | I | 3 | |
| Z. Wang et al., 2018 | na | 1 | |
| C. Li et al., 2019 | na | 34 | |
| Y. Zhao et al., 2019 | prospective | 95 | |
| L. Zhang et al., 2019 | II | 40 | |
| Melanoma | Niu et al., 2011 | na | 2 |
| Jinying Zhang et al., 2012 | na | 6 | |
| Hong Li et al., 2017 | na | 55 | |
| F. Chen et al., 2017 | na | 1 | |
| Hong et al., 2016 | na | 4 | |
| Multiple myeloma | Laport et al., 2011 | na | 3 |
| X. Zhou et al., 2013 | na | 2 | |
| Y. Liu et al., 2016 | retrospective | 1 | |
| Y. Luo et al., 2016 | I | 2 | |
| Introna et al., 2017 | II a | na | |
| Myelodysplastic syndrome | B. Yang et al., 2012 | pilot | 5 |
| Introna et al., 2007 | I | 2 | |
| Introna et al., 2017 | II a | na | |
| Narayan et al., 2019 | II | 27 | |
| Nasopharyngeal carcinoma | Y. Li et al., 2015 | retrospective | 112 |
| C.-L. Chen et al., 2018 | I | 1 | |
| J.-J. Zhao et al., 2018 | retrospective | 85 | |
| Ovarian cancer | Niu et al., 2011 | na | 1 |
| J. Liu et al., 2014 | na | 46 | |
| Z. Zhang et al., 2015 | retrospective | 4 | |
| C. Zhang et al., 2017 | na | 2 | |
| C.-L. Chen et al., 2018 | I | 1 | |
| Y. Zhou et al., 2019 | retrospective | 72 | |
| Pancreatic cancer | Jinying Zhang et al., 2012 | na | 3 |
| M. Wang, Shi, Qi, Tang, & Tian, 2013 | prospective | 28 | |
| Chung, Park, Bang, Park, & Song, 2014 | II | 20 | |
| Z. Zhang et al., 2015 | retrospective | 1 | |
| Z. Wang et al., 2016 | retrospective | 25 | |
| N. Jiang et al., 2017 | prospective | 36 | |
| C. Li et al., 2019 | na | 2 | |
| Prostate cancer | J. Yu et al., 2011 | na | 1 |
| Sarcoma | J. Yu et al., 2011 | na | 1 |
| Jinying Zhang et al., 2012 | na | 2 | |
| F. Chen et al., 2017 | na | 2 | |
| Hong et al., 2016 | na | 1 | |
| Thyroid cancer | J. Yu et al., 2011 | na | 4 |
| Ureter cancer | Jinying Zhang et al., 2012 | na | 1 |
| Total | 4551 | ||